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Some bacteria are naturally resistant to certain antibiotics, but others can acquire resistance through mutations or horizontal gene transfers via transformation, transduction or conjugation [32, 33]

By improving atherogenic dyslipidaemia, resmetirom might secondarily attenuate cardio-renal progression, whereas semaglutide has already shown nephro-protective and potential anti-neoplastic signals in large T2DM trials [58, 59]

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